Seth Rogen's wife Lauren Miller Rogen has no issues directing him to kiss women on screen.

The 45-year-old filmmaker is at the helm of her actor husband's new movie Babies in which he joins Anna Kendrick, 41, as a married couple debating whether or not they want children, and they have to lock lips on the big screen.

Lauren told PEOPLE magazine: "Listen, I have watched him make out with beautiful women for literally decades at this point.

"So it's nothing new to add another beautiful woman to that list."

Anna quipped: "No, if anything, Lauren was like, 'Get in there!'"

Lauren laughed: "I literally would be like, 'Can you be a little bit closer?'

"And I feel like everyone in our crew was like, 'Lauren is really not bothered by this at all.' So yeah, it was great."

Seth, 44, married Lauren back in 2011, having first been introduced by mutual friend six years earlier.

She has appeared in several of his big screen comedies too, including Superbad, Sausage Party and Zack and Miri Make A Porno.

Babies is a "very personal" one for the couple, who have been open in the past about their decision not to have kids of their own.

Seth said: "I think it's very brave to write something very honest and I was really thrilled that she was taking something so personal and turning it into a film about a thing that I hadn't really seen before.

"And I thought that the way that our relationship is reflected in the movie and the world surrounding us, it all feels very honest, which I think is all you can really go for."

While Lauren is on board with anything Seth has to do for a role, he previously revealed an awkward moment during a sex scene with Penelope Cruz for The Invite, which was helmed by Olivia Wilde.

He told Jimmy Kimmel Live!: "What's actually funny in the scene is we were encouraged to improvise.

"There's a scene where me and her are having a romantically-charged moment and it seems like we might hook up with one another, and I just kept saying 'Thank you.'

"And Olivia Wilde, the director, was just like, 'Why? What are you doing? Why do you keep saying 'Thank you'?

"And I was like, 'I don't [know]. It's just what's coming out of my mouth.'

Rogen joked that if he was in the same situation in real life he would have plenty of "gratitude" for Penelope.

He said: "I would be apologetic and thankful. I'm sorry."